Strength of Antimicrobial Bone Cement Decreases with Increased Poragen Fraction
AbstractBackgroundAdding soluble particulate poragens to antimicrobial-loaded bone cement increases the permeability of the bone cement and increases the antimicrobial release, but the mechanical...
View ArticleMixing Method Affects Elution and Strength of High-dose ALBC: A Pilot Study
AbstractBackgroundHigh-dose antimicrobial-loaded bone cement (ALBC) is used to treat orthopaedic infections. High-dose ALBC is not commercially available and requires surgeon directed formulation, and...
View ArticleDistribution of Locally Delivered Antimicrobials Is Limited by Cortical Bone:...
AbstractBackgroundLocal delivery is required to achieve the high antimicrobial concentrations needed to treat biofilm-forming infections. The delivery site is commonly either in the intramedullary...
View ArticleVoriconazole Is Cytotoxic at Locally Delivered Concentrations: A Pilot Study
AbstractBackgroundFungal infections are rare but major problems when they involve orthopaedic implants. Preferred treatment in North America is two-staged: resection and then delayed reconstruction,...
View ArticleHave Levels of Evidence Improved the Quality of Orthopaedic Research?
AbstractBackgroundSince 2003 many orthopaedic journals have adopted grading systems for levels of evidence (LOE). It is unclear if the quality of orthopaedic literature has changed since LOE was...
View ArticleBiofilm Growth Has a Threshold Response to Glucose in Vitro
AbstractBackgroundHyperglycemia is a risk factor for nosocomial infections with known host effects. Increased glucose levels also increase pathogenicity of infecting microbes through greater biofilm...
View ArticleAntimicrobial Distribution From Local Delivery Depends on Dose
AbstractBackgroundTissue distribution after local delivery has been quantified over a period of 5 hours on 7-T MRI in a rabbit model using gadolinium-labeled diethylenetriamine pentaacetic acid...
View ArticleLocal Gentamicin Delivery From Resorbable Viscous Hydrogels Is...
AbstractBackgroundLocal delivery can achieve the high antimicrobial concentrations necessary to kill biofilm-related microbes. Degradation times for resorbable carriers are too long. Hydrogels (gels of...
View ArticleAntimicrobial Release From Prefabricated Spacers Is Variable and the Dose Is Low
AbstractBackgroundHigh-dose antimicrobial-loaded bone cement (ALBC) is recommended to treat orthopaedic infections. Elution characteristics from prefabricated ALBC spacers and how they compare with...
View ArticleBiofilm Antimicrobial Susceptibility Increases With Antimicrobial Exposure Time
AbstractBackgroundThe antimicrobial concentration required to kill all the bacteria in a biofilm, known as the minimum biofilm eradication concentration (MBEC), is typically determined in vitro by...
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